Adipose SVF Stem Cell Therapy for Neurologic Diseases
Mesenchymal stem cells (MSCs) have been used in over 500 clinical trials. The main sources of MSCs are bone marrow and adipose tissue. Adipose-derived stem cells are called stromal vascular fraction (SVF), which differentiate into cartilage, muscle, tendon, nerve, bone, and muscle cells. many stem cells have been explored for the treatment of many neurologic diseases. various neurologic diseases are being cured with stem cell therapy.
What are SVF and Adipose Stem Cells?
The subcutaneous adipose tissue is fat tissue. This tissue is a source of autologous stem cells, which are used for many cell-based therapies. Adipocytes (fat cells) from SVF contribute to the secretory function of adipose tissue. These cells are the main source of leptin and adiponectin (hormones) as well as inflammatory cytokines. The SVF portion of fat is composed of supra-adventitial cells, pericytes, endothelial cells, macrophages, and fibroblasts. The pericytes have regenerative potential.
Macrophages accumulate in the adipose SVF, and they contribute to chronic inflammation because of proinflammatory molecule production. SVF therapy is used because it has anti-inflammatory characteristics, and is capable of regenerating damaged and injured body structures.
The adipose tissue is collected from the abdominal region. A local anesthetic is used to numb the tissue, and a small incision is made. The tissue is irrigated with a solution made of sterile saline, epinephrine, and lidocaine. Around 200 milliliters of fat are removed by inserting a small cannula and suctioning the thick yellow tissue.
After removal, the incision is closed with sutures. The cells are treated with a collagenase solution and then centrifuged (spun). The resulting solution is the SVF.
The SVF solution is given to the patient via intravenous administration or by injecting the solution into the diseased or injured body part. The average cell content per one milliliter of adipose tissue is around 1 million.
Conditions Treated with SVF
Stromal vascular fraction therapy has been proven to have immune-modulation properties. Stem cells have been found to “reboot” the immune system. There is much evidence that neurologic diseases or neurologic conditions respond to stem cell therapy. Conditions treated include:
- Parkinson’s disease
- Multiple sclerosis (MS)
- Reflex sympathetic dystrophy
- Painful bladder syndrome
Safety and Efficacy of Stem Cell Therapy
In a recent study, stem cells were given to patients with multiplex sclerosis disease like the neurologic diseases of the central nervous system. There were 145 people in the study who received 480 stem cell injections into the ligaments, tendons, neurologic diseases or muscle, or intrathecally (into the spinal region). The results showed that the procedure was safe, with no adverse reactions noted.
In a recent clinical study, mesenchymal stem cells were used for multiple sclerosis. The cells were given to patients over a 4-year period. Researchers found that clinical and radiological disease was suppressed after treatments. In another study, patients with multiple sclerosis received one dose of intrathecal MSCs. After therapy, the patients either improved or stabilized. stem cell therapyPhoenix clinic is the best choice for the treatment of neurologic diseases. stem cell therapy is a surgery-free treatment for neurologic diseases.
How Stem Cells Work
The therapeutic effects of SVF stem cells have been demonstrated in many animal studies. In one study involving immune modulation, researchers showed that administration of stem cells in bovine myelin prevented the onset of mouse MS-like disease. In addition, investigators found that stem cells stimulated Treg cells, which led to apoptosis of activated T cells. Several other studies showed inhibition of EAE after stem cell injections.
In another clinical study, stem cells were found to promote central nervous system repair in patients with MS. Researchers found that stem cells showed a consistent pattern of gene expression changes that were associated with increased homogeneity. Stem cells also produced an immunoregulatory function that was related to the secretion of bioactive factors.
Hou ZL, Liu Y, Mao XH, et al. (2013). Transplantation of umbilical cord and bone marrow-derived mesenchymal stem cells in a patient with relapsing-remitting multiple sclerosis. Cell Adh Migr, 7(5), 404-407.
Mohyeddin-Bonab M, Mohajari M, Sahraian MA, et al. (2014). Evaluation of cytokines in multiple sclerosis patients treated with mesenchymal stem cells.
Siennicka K, Zolocinska A, Stepien K, et al. (2016). Adipose-Derived Cells (Stromal Vascular Fraction) Transplanted for Orthopedical or Neurological Purposes: Are They Safe Enough? Stem Cells International.